ALSAVIN Intra-Articular Injections (IAls) are used to restore the limited mobility of patients because of the discomfort experienced due to osteoarthritis and to help them move freely and maintain a quality life.
High Molecular Weight
3.0 MDa * long and monotype Ha chains prevent molecular separation and support stability for pain relief.
Suspensive HA Structure
HA suspensive properties and the distance between HA chains support stress absorption at the molecular level.
High Dynamic Viscosity
shows’ shear thinning' like healthy human synovial fluid under increased mechanical stress frequency that provides articular motion compatibility and smooth movements.
ALSAVIN IAls is sterile, non-pyrogenic, clear, non-inflammatory, highly purified sodium hyaluronate of high molecular weight. The rigorously purified sodium hyaluronate is manufactured by bacterial fermentation.
The elasticity of intra-articular HA products plays a significant role in pain relief. The Adaptive Elasticity is increased by the stress frequency. Provides progressive shock absorption while presenting highly elastic and suspensive responses.
High Molecular Weight
High Dynamic Viscocity
Suspensive HA Structure
High-Molecular Weight NaHA for 3-5 injections with 1 week intervals
High-Molecular Weight NaHA for 1-3 injections with 1 week intervals
High-Molecular Weight NaHA for Mono Dose, one-shot injection
Elacticity of intra-articular HA products plays a significant role in pain relief. The Adaptive Elasticity of ALSAVIN IAIs is increased by the stress frequency. Provides progressive shock absorption while presenting highly elastic and suspensive responses.
Exhibits a more elastic response than synovial fluid in static conditions (0 - 0.5 Hz).
Protexts total cartilage from gelgind and stiffness while under static conditions or after long inactivity.
More suspensive than synovial fluid under dynamic conditions (2.5 Hz).
Higher elastic modulus of ALSAVIN at 2.5 Hz yields greater elastic behavior and enhanced suspensive properties under dynamic conditions. Thus protecting the material and cartilage from deformations.
Frequently Asked Questions
What is hyaluronic acid and how does it help osteoarthritis?
Sodium hyaluronate is a high molecular weight, a ubiquitous molecule that occurs naturally within the cartilage and all synovial joints. In particular, weight-bearing joints, such as ankles, knees, and hips, contain viscoelastic sodium hyaluronate. This substance has lubrication and shock-absorbing properties, allowing these joints to move normally and painlessly.
In patients with osteoarthritis, the viscoelasticity of the fluid within the synovial joint is significantly impaired, causing mechanical stress on the joint, breakdown of the articular cartilage, and, subsequently, limited and painful joint movement.
Adding hyaluronic acid to the existing joint fluid of an osteoarthritic knee helps to facilitate better knee movement, reduces pain, and has many more benefits.
Why is hyaluronic acid important in the treatment of osteoarthritis?
Hyaluronic acid (HA) injections offer several advantages over other treatment options. These intra-articular injections, with their exceptional viscoelastic properties of highly purified sodium hyaluronate, help to improve the quality of a joint’s lubrication. This increased lubrication aids in shock absorption, reducing pain and improving joint mobility.
These beneficial effects may last for several months, following the recommended treatment cycle of intra-articular injections. Additionally, hyaluronic-acid products minimize the risk of systemic side effects and may even delay the need for total knee replacement.
Where Alsavin stand for Pain Relief and Osteoarthritis?
Viscosupplement injections a substance similar to healthy joint fluid is one of the effective non-surgical treatment. Alsavin is injected into the joints to supplement and lubricate damaged joint fluid, reduce pain and povide movement freedom.
What are the indications for Alsavin treatment?
Alsavin 1.0% / Alsavin Supra 1.6% / Alsavin One 2.0% is a product for the relief of the pain and stiffness of the knee joint and other synovial joints in patients with degenerative and traumatic changes to synovial joint. Alsavin 1.0% / Alsavin Supra 1.6% / Alsavin One 2.0% contains sodium hyaluronate, sodium chloride, disodium hydrogen phosphate, sodium dihydrogen phosphate and water for injection.
How soon after an Alsavin treatment will a patient experience pain relief?
A patient will experience pain relief within a few days after treatment. The patient should not strain their knee joint for two days after receiving Alsavin and should avoid activities such as jogging, soccer, tennis, heavy lifting, or standing for long periods. Temporary pain or swelling of the knee joint may occur after receiving a hyaluronic-acid injection.
How long will pain relief last after an Alsavin treatment?
A patient can expect to experience pain relief from an Alsavin treatment for 6 – 9 months. This effect may last for several additional months following a recommended treatment cycle of intra-articular injections.
How is an Alsavin treatment administered and can a treatment be repeated?
Alsavin 1.0% is five injections in a one-week interval; Alsavin Supra 1.6% is three injections in a one-week interval, and Alsavin One 2.0% is a one-shot injection. Depending on the patient’s condition and the doctor’s suggestion, these treatments may be repeated.
How often can a patient receive Alsavin injections?
Alsavin’s effectiveness in reducing pain lasts from 6 – 9 months. As recommended, after 6 months, a patient should have the injections again.
Can a patient receive Alsavin injections in more than one joint at the same time?
Several joints may be treated simultaneously; however, to avoid intra-articular infection, it is essential to apply the strict aseptic-injection technique. Do not reuse a syringe. Any repeat usage of a syringe carries a risk of contamination and infection of the patient.
What are contraindications for HA injections?
HA injections should not be administered to patients with known hypersensitivity to sodium-hyaluronate preparations. Additionally, intra-articular injections are contraindicated in cases where infections or skin diseases are present in the area of the injection site to reduce the potential for developing septic arthritis.
What are the side effects of Alsavin injections?
Following the use of Alsavin 1.0% / Alsavin Supra 1.6% / Alsavin One 2.0%, patients may experience localized symptoms in the joint being treated, such as pain, the sensation of heat, reddening, and swelling. The following adverse events have been reported for similar products: mild, or moderate arthralgia, in rare cases skin rash, aseptic joint effusions, pruritus, and muscular cramps. Further adverse events that have been observed in very rare cases are allergic reactions, anaphylactic shock, hemarthrosis phlebitis, pseudosepsis, severe acute inflammatory reaction (SAIR), nasopharyngitis, joint stiffness, tendonitis, bursitis, fever, and myalgia.
What other treatments are available for osteoarthritis?
Treatment is chosen according to the grade of osteoarthritis. Drugs, such as glucocorticoids and NSAIDs, have been widely used for the treatment of osteoarthritis; however, none of these agents provides complete treatment and they have all been associated with adverse effects.
Recently, new treatment strategies are being proposed, including anti-cytokine therapy, gene therapy, delivery of growth factors, stem-cell therapy, neurotransmitter antagonists, bisphosphonates, and lubricant agents, such as lubricin.
What is the origin of Alsavin?
Alsavin 1.0% / Alsavin Supra 1.6% / Alsavin One 2.0% is sterile, non-pyrogenic, clear, non-inflammatory, highly purified sodium hyaluronate of high molecular weight, dissolved in a buffered physiological saline solution. The highly purified sodium hyaluronate is obtained from bacteria by fermentation.
What is the molecular weight of Alsavin?
The molecular weight of Alsavin is 3MDa, which is one of the highest non-animal-sourced molecular weights on the market.
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